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POC (Products of Conception)


IVF

Overview

  • 50% of miscarriages in the first trimester are caused by chromosomal abnormalities.
  • For women undergoing assisted reproduction treatment this proportion is 60% and increases with the woman’s age.
  • All 24 chromosomes are analysed to identify the reason for the pregnancy failure.
  • The mother’s blood is taken to rule out any contamination in the foetal sample.
  • Information from the POC test can help patients choose future reproductive options to ensure a healthy pregnancy.

Benefits

  • Results are obtained in >98% of cases.
  • Results are available quickly as cell culture is not required.
  • False negative results caused by maternal contamination can be ruled out.
  • STR microsatellite (DNA fingerprinting) technology is used to identify the maternal or foetal origin of the material analysed.
  • NGS has higher resolution than a conventional karyotype.
  • Can be performed on twin pregnancies.

Indications

The POC test is suitable for:

  • Women who have suffered a pregnancy loss.
  • Women who have experienced recurrent miscarriages.
  • Couples undergoing assisted reproduction treatment, as useful information to guide future treatment choices.