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Archive for December 2018

ivf success stories

ICSI Positive Patient – After 10 Years of Sub-fertility at Australian Concept Infertility Medical Center

Beautiful Baby boy M.Rehan was born after ICSI treatment and Allah’s Blessings.

Parents : Mr. Bashir & Mrs. Kalsoom Bibi

ACIMC has been offering State of the ART Infertility Treatment since 1998, including

ICSI

IVF

PGD

IUI

LAPAROSCOPY

FET

GENDER SELECTION

GENDER BALANCING

FAMILY BALANCING

TEST TUBE

AZOOSPERMIA

Australian Concept Infertility Medical Center – Best Infertility / Subfertility Treatment via IVF / ICSI / FETTesttube

Read More
IVF Success Stories

ICSI Positive Patient – After 10 Years of Sub-fertility at Australian Concept Infertility Medical Center

Beautiful Baby boy was born after ICSI treatment and Allah’s Blessings.

Parents : Mr. Zafar & Mrs. Asia Zafar

ACIMC has been offering State of the ART Infertility Treatment since 1998, including

ICSI

IVF

PGD

IUI

LAPAROSCOPY

FET

GENDER SELECTION

GENDER BALANCING

FAMILY BALANCING

TEST TUBE

AZOOSPERMIA

Australian Concept Infertility Medical Center – Best Infertility / Subfertility Treatment via IVF / ICSI / FETTesttube

Read More

PGD Positive Patient – After 10 Years of Sub-fertility at Australian Concept Infertility Medical Center

10 years of Infertility treated Successfully at Australian Concept Infertility Medical Center.

ACIMC has been offering State of the ART Infertility Treatment since 1998, including

ICSI

IVF

PGD

IUI

LAPAROSCOPY

FET

GENDER SELECTION

GENDER BALANCING

FAMILY BALANCING

TEST TUBE

AZOOSPERMIA

Australian Concept Infertility Medical Center – Best Infertility / Subfertility Treatment via IVF / ICSI / FETTesttube

Read More

What is Hyperstimulation?

The purpose of infertility treatment including IVF and other assisted reproductive techniques is to increase the chances of infertility for infertile couples. This treatment is intended to stimulate the ovaries to ensure that several ovarian follicles are developed instead of just one that develops in a normal natural cycle. This helps the doctors to collect several oocytes (eggs) and eventually several embryos to be transferred into a female uterus.

OVARIAN HYPERSTIMULATION SYNDROME :

Ovarian Hyper stimulation syndrome commonly called as OHSS is a rare iatrogenic syndrome, which occurs as a result of these ovarian stimulation treatments and fertility drugs for ovulation. The most commonly used fertility drugs are the gonadotropin drugs, clomid and letrozole.

Gonadotropins includes FSH and LH and are used in injectable form whereas clomid and letrozole are taken orally. The purpose of both is to stimulate the ovaries in order to obtain increased number of oocytes at the time of egg retrieval.

WHO clinical classification:

The classification of Ovarian Hyper Stimulation Syndrome is based on the signs and symptoms experienced by the female patients, and are divided into mild, moderate and severe forms, based on the degree of their severity these are classified as the following;

Mild OHSS:

Increase in Ovarian volume, less than 5cm

Excessive steroid production

Pelvic discomfort

Moderate OHSS:

Increase in Ovarian volume, between 5cm to 12cm

Abdominal Distension

Digestive problems like nausea, vomiting and diarrhea

Severe OHSS:

Increase in Ovarian volume, greater than 12cm

Renal failure

Ascites (accumulation of excess fluid in the abdomen or peritoneal cavity)

Pleural effusion (accumulation of excess fluid in the pleural cavity, between the layers of the lungs and the rib cage)

Coagulation disorders (blood disorders leading to disruption of clot formation and hence bleeding)

This classification helps to determine the type of treatment required, should the patient experience ovarian hyperstimlutaion signs and symptoms. Normally the infertility specialists are familiar with these signs and symptoms, and hence are able to detect them in order to provide appropriate treatment required. Since these are serious complications and can be potentially life threatening if left untreated, they should be catered to very effectively.

If you experience any of the above mentioned signs and symptoms during an ovarian stimulation cycle, you should consult your doctor immediately and pay him or her a visit.

Risk Factors:

The risk of having hyperstimulation can be prevented by screening the patients for risk factors, this should be considered before starting the treatment.

The Risk Factors of having the complication of Ovarian Hyper stimulation syndrome are as follows;

Your age is 30 years or younger

You have Polycystic ovarian syndrome

Your AMH (Anti Mullerian Hormone) levels are high

You are underweight

You have a history of developing OHSS in the past

This means a younger patient with a normal ovarian reserve and with polycystic ovarian syndrome is at a higher risk of developing hyperstimulation complications than an older patient with a decreased ovarian reserve. To check for ovarian reserve, the most commonly used test by our doctors is the level of Anti Mullerian Hormone (AMH).

Prevention of OHSS

When starting the infertility treatment, your specialist doctor must take in consideration, your age, your ovarian reserve, your hormonal levels and the possibility of having polycystic ovarian syndrome, in order to avoid ovarian hyperstimulation.

Also after starting the treatment, your doctor would follow the stimulation response to fertility drugs, using blood tests and ultrasound, and so the gonadotropin doses must be tailored according to individual patient’s response. Thus, if your doctor notices an excessive response to ovarian stimulation, he or she should decrease the dose accordingly.

Although hyperstimulation occurs only after ovulation has taken place, your doctor can still look for signs that suggest increased risk during a particular cycle. If that’s the case, then in response to the fertility drugs, your ovaries will develop an increased number of follicles than expected, and the estradiol or estrogen level in your body would also be higher than normal, meaning that your chances of having OHSS in this cycle are high.

Ideally under such circumstances the doctor would cancel your treatment because pregnancy can worsen OHSS. Your doctor would cancel the insemination process and would advise you to avoid having intercourse if you were undergoing an IUI (intra uterine insemination). Whereas if you were undergoing an IVF treatment then any fertilized embryos would be frozen and saved to be transferred into your uterus at a later date, when your body allows.

An alternative to this cancellation of ovarian stimulation treatment is delaying ovulation and the process is called ‘coasting’. This is achieved by prescribing a Gonadotropin releasing hormone antagonist commonly called GnRH antagonist, that would prevent the LH surge, which is required for ovulation. This delay lowers the risk and severity of complications and increases the chances of carrying on with a successful pregnancy.

One should not exert themselves thinking of these complications, instead you should be in contact with your doctor during the entire process and inform him or her about any alarming signs. Of course your doctor would provide you with the relevant information and material, we have come across some pamphlets delivered by an infertility clinic called Australian concept infertility center, it had a lot of relevant information on hyperstimulation.

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ivf success stories

ICSI Positive Patient – After 13 Years of Sub-fertility at Australian Concept Infertility Medical Center

13 years of Infertility treated Successfully at Australian Concept Infertility Medical Center.

Beautiful Baby boy M. Abdul Hammad was born after ICSI treatment and Allah’s Blessings.

Parents : Mr. Imran & Mrs. Sara Imran

ACIMC has been offering State of the ART Infertility Treatment since 1998, including

ICSI

IVF

PGD

IUI

LAPAROSCOPY

FET

GENDER SELECTION

GENDER BALANCING

FAMILY BALANCING

TEST TUBE

AZOOSPERMIA

Australian Concept Infertility Medical Center – Best Infertility / Subfertility Treatment via IVF / ICSI / FETTesttube

Read More

Delayed Embryo Transfer

During the course or struggle of infertility, the most important process is of embryo transfer and even more crucial is the right time for this process to be performed. Thus, it is very important for our infertility specialists to choose the right time for embryo transfer, that being the time with which our patients could benefit the most and have the highest chance of conceiving.

Embryo transfer is the technique performed at many infertility clinics including Australian concept infertility Center with the help of our infertility specialists as well as the embryologists, who work as a team to transfer the embryo with in a female uterus.

However, when this technique is delayed for different reasons, the major reason being patient welfare then it is called ‘delayed embryo transfer’

In delayed embryo transfer the fertilized embryo of our IVF (in vitro fertilization) patient are frozen so that they can be used in the future and be transferred in the female uterus when the conditions are feasible.

What is an embryo?

As a normal method of sexual reproduction in human beings, when an egg cell and a sperm cell, from a female and a male body respectively are fertilized they form a single celled organism called zygote, this zygote then undergoes cellular division to form an organism called embryo, which undergoes further growth and eventually forms into a fetus.

When this process of fertilization takes place outside a women’s body, and in a petri dish inside a lab, it is called in vitro fertilization (IVF). An egg is retrieved from a female body after closely monitoring her ovulatory process and a sperm is retrieved from a semen sample of a male, these are then manually combined to form an embryo. The sperm is directly injected within the cytoplasm of an egg and this procedure is called intra cytoplasmic sperm injection (ICSI).

The in vitro fertilization process is given approximately five days for the embryo to divide and grow in size, it goes through the division cycle of two-cell, four-cell and eventually eight-cell embryo. The formation of an eight-cell embryo on day three of in vitro fertilization is considered a very good sign and points towards higher chances of success.

What actually is Embryo transfer and delayed embryo transfer?

Once an embryo is formed ‘in vitro’, it can be used in the following ways;

Either it can be transferred to the female uterus during the same ovulation cycle in which her eggs were retrieved and fertilized, this is called a fresh cycle embryo transfer. This includes all the stages of egg retrieval, fertilization, culture in lab for several days and embryo transfer during one menstrual cycle.

Or they can be frozen and used later for transfer and eventually implantation, this is called a delayed embryo transfer. This involves the freezing or cryopreservation of good quality embryos for future use, these frozen embryos can be used in the next cycle or after months and even after years, embryos frozen for as long as 10 years have also been reported to be successfully implanted!

Depending on a female’s condition during the egg retrieval cycle, the infertility specialists and embryologists decide whether to go for a fresh cycle embryo transfer or a delayed embryo transfer.

Considering the enhanced and improved techniques of embryo freezing now, many specialists opt for freezing all good quality embryos and use them once the recipient female’s uterus and ovaries have returned to a normal condition seeing that she has undergone intense hormonal stimulation during the ovulatory process and during the egg retrieval procedure.

What happens after the embryo is transferred?

Most couples ask this question, of course concerned about the fate of the new baby they just helped making, with an IVF treatment. They want to know the chances of them becoming parents with this embryo.

Well once the embryo is transferred to a women’s uterus, the final hurdle for the embryo to overcome is to get implanted! And this depends on the egg quality, sperm quality and then the embryo quality that resulted from the fertilization of the former two.

A brief description of what happens to an embryo after being transferred;

-The blastocyst continues to divide and emerges from its shell,

-It then starts to attach itself to the uterine lining,

-Once the blastocyst invades the uterine lining the process of implantation occurs and the women may experience some bleeding or spotting, however no bleeding doesn’t mean you have not conceived,

-The embryo then digs deeper and starts getting blood supply from the maternal blood vessels,

-As it continues to grow, a hormone called human chorionic gonadotropin (HCG) is released in the blood stream,

-More HCG is released when fetal development is in full swing and the placenta has developed,

-This is when one can take the home urine pregnancy test, around the 9th day of transfer however we at Australian concept infertility medical Center prefer you wait till 10-12 days for a blood beta-hcg test which is much more reliable. We give our couples a date to come and get tested for pregnancy and we love to give our couples the good news ourselves!

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What is Polycystic Ovarian Disease ?

 

One of the most common hormonal disorder associated with the female ovaries is POLYCYSTIC OVARIAN DISEASE, commonly called as PCOD. It causes infertility, hence has become a growing concern for females trying to conceive.

Role of ovaries in a female reproductive system.

To understand clearly what exactly is Polycystic ovarian disease one must know the function of the female ovaries as well as the knowledge of its role in reproduction because ovaries are a very important organ in a female’s reproductive system. Not only that, they are also very important in terms of fertility. Every normal female has a pair of ovaries in her lower abdomen, these are the female reproductive glands situated on either side of the uterus and connected to the uterus through the Fallopian tubes. The function of these ovaries is to form the ova or eggs and release them (eggs) into the uterus every month. They are solid, ovoid structures each measuring about 1 centimeter in thickness, 3.5 cm in length and 2.5 cm in width. As mentioned earlier ovaries are the reproductive glands and hence release hormones mainly; estrogen and progesterone. This release of hormones is under the influence of hypothalamus and is triggered by it.

Estrogen and progesterone are extremely important for a normal growth of the female reproductive system as well as for fertility. They regulate the female menstrual cycle, the growth of secondary sexual characteristics in a female at puberty as well as the ovulation process.

What is ovulation?

When a girl hits puberty, the ovulation occurs, it is a process in which one egg is released from an ovary each month, the ovaries usually take alternate cycles to release an egg.

The pituitary gland receives a signal from the hypothalamus to release two hormones, Follicle Stimulating Hormone (FSH) and Luteinizing hormone (LH) called the gonadotropic hormones. One should bear in mind that a female or a baby girl is born with an egg reserve, which means that she is born with all the eggs of her lifetime and these eggs are contained in the follicles that are found inside the ovaries. So at puberty each female starts her menstrual cycle with approximately 400,000 eggs. These eggs mature within a follicle before they are released and this release is under the influence of FSH and LH. The FSH causes growth of an egg while the LH Is responsible for the release of an egg from the ovary.

What happens to the egg after being released from an ovary?

Once the follicle ruptures, the egg is released from the ovary and captured by the fallopian tubes and guided through to the uterus through the muscular contractions of the tubes. It is during this time and within 24 hours of egg release that fertilization of the egg with a sperm can take place in order to form an oocyte which later undergoes multiple cell divisions to form an embryo. If an egg is not fertilized within 24 hours of its release it begins to degenerate.

POLYCYSTIC OVARIAN DISEASE

It should be much easier to understand PCOD now that we have some knowledge about the ovaries, the ova and the hormones involved.

As the name suggests PCOD occurs when the ovaries develop multiple cysts, (poly means many) making the ovaries look bulky or enlarged because these are not the functional cysts that disappear instead they remain and occupy a large area of the ovaries. Therefore, the development of these cysts hinders the normal function of an ovary of releasing an egg in turn causing infertility issues because as discussed earlier the process of ovulation is essential for a female to conceive and get pregnant.

It not only affects the ovulation process but also disturbs the menstrual cycle causing irregular periods and infertility. In addition to this the presence of these cysts causes hormone imbalance as well, increased number of cysts cause the release of a hormone called androgen instead of estrogen, androgen is a male hormone and it is the main reason why females with PCOD have facial hair and chest hair, because the male hormone follows the male hair distribution pattern.

Symptoms of PCOD?

Not all women with PCOD have the same symptoms but irregularity of menstrual cycle is the most common symptoms, other symptoms include; Acne, irregular periods or complete absence of periods, excessive hair growth and at unusual places, pelvic pain, weight gain, mood swings and the most important infertility!

What causes of PCOD?

The exact cause of PCOD is yet to be discovered, but some factors play an important in leading to this condition, they include;

Heredity, if a mother has multiple cysts in her ovaries, the daughter is most likely to inherit it.

Excess androgen production, androgens are male hormones but are found in excess in a PCOD female.

Insulin resistance, if a human body resists insulin then there is excess production of insulin in the body this in turn leads to excess androgen production and eventually difficulty in ovulation.

In our society, infertility is a very serious concern as it determines the future of a female.

Thankfully today we have infertility specialists and infertility centers like Australian concept infertility center where it is not impossible to have a baby even if you are suffering from Polycystic ovarian disease, thanks to our infertility specialists and our expertise in assisted reproductive techniques. We treat PCOD with medications and in some cases use the assisted reproductive techniques, if required, which include ICSI, IVF, TEST TUBE BABY. We are making it possible for our PCOD patients to conceive and have a life that they imagined with their own children.

 

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ivf success stories

ICSI Positive Patient Success Story – After 7 Years of Sub-fertility at Australian Concept Infertility Medical Center

7 years of Infertility treated Successfully at Australian Concept Infertility Medical Center.

Patient : Mr. Shahbaz Sarwar & Mrs. Maria Liaqat

ACIMC has been offering State of the ART Infertility Treatment since 1998, including

ICSI

IVF

PGD

IUI

LAPAROSCOPY

FET

GENDER SELECTION

GENDER BALANCING

FAMILY BALANCING

TEST TUBE

AZOOSPERMIA

Australian Concept Infertility Medical Center – Best Infertility / Subfertility Treatment via IVF / ICSI / FETTesttube

Read More