X and Y chromosomes determine the sex of the baby, common anomalies include; XXX, XXY (Klinefelter syndrome), monosomy X (Turner syndrome).
During pregnancy, the DNA of the baby, growing in the mother’s womb is found in maternal plasma. A maternal blood sample drawn after 10 weeks of pregnancy has sufficient amount of fetal DNA circulating in it, to be tested and to give accurate results.
-More accurate than the combined First Trimester screening tests.
-Enables us to test twin pregnancies.
-It benefits women of all ages, ethnicities and BMI (Body Mass Index)
-Reduces the need for amniocentesis, requires a standard maternal blood test.
-The rate of information obtained is 99.9% of the sample analyzed.
-Involves the detection of all 24 chromosomes as well as of 5 micro deletions, which are found in major genetic abnormalities.
-Early detection; from the 10th week of gestation.
-Along with detecting the aneuploidies, NACE can also be used to detect the gender of the future baby as early as the 10th week of pregnancy.
Doctors recommend NIPT for all pregnant women, but target the following women more;-Those who had an abnormal first trimester screen result.
It is a highly sensitive and specific test that can be performed on both single and twin pregnancies.It can also be performed on In Vitro Fertilization (IVF) cases and in cases where gestation takes place through oocyte donations.
-The probability of getting a false negative or a false positive result is low.
-Prevents the mother to undergo unnecessary amniocentesis, a test that carries the risk of miscarriage.
-Out of every twenty females tested, only one will be tested positive for carrying a baby with Down syndrome.
In the case of a positive result, what’s next?-Post test genetic counseling.